Intravenous therapy offers a broad range of benefits to treat medical issues and elective health enhancement within the out-patient, urgent care, clinical office and mobile clinic settings. Compared with other routes of administration, the intravenous route is one of the fastest ways to deliver bioavailable fluids and medications throughout the body. The many benefits of IV therapy can be associated with risk and complications but our purpose is to provide a comprehensive, standard operating procedure (SOP) manual to decrease risks; improve outcomes and through standards and practice guidelines run a successful clinic. This comprehensive peer reviewed manual will discuss all aspects of IV therapies from conventional hydration, nutritional therapies, and new boutique intravenous therapies. The IV Institute has worked with many offices and practitioners to establish policies and procedures that enables the practitioner to easily implement IV therapy with confidence and success.